Structural and functional biomarkers of the effect of navigational repetitive transcranial magnetic stimulation in patients with drug-resistant depression

The use of high-frequency repetitive transcranial magnetic stimulation (rTMS) in patients with a drug-resistant depressive episode is associated high variability its effect, which determines the relevance search for predictive biomarkers effect. Objective: to neuroimaging clinical effectiveness navigational rTMS episode. Patients and methods. study included 30 drug resistant who underwent 20 sessions highfrequency dorsolateral prefrontal cortex (DLPFC) left hemisphere. We performed an analysis correlations between functional connectivity gray matter volume (GMV) given areas (before rTMS) degree reduction Beck score assessment depression presence clinically significant response therapy. Results discussion. A relationship was shown effect low values subgenual cingulated DLPFC right found decrease severity symptoms GMV insula, inferior frontal gyrus, temporal pole, superior median cingulate hemisphere, as well therapy pole gyrus on left. Conclusion. obtained results may become prerequisite development individual